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JFSF Vol 6, No 1, March 2021, p.25-31

doi: 10.22540/JFSF-06-025


Original Article

Association of Monocyte Chemotactic Protein-1 and Dickkopf-1 with Body Composition and Physical Performance in Community-Dwelling Older Adults in Singapore

Nathania Octaviani Afandy1,2*, Hui Shan Lock1,3*, Laura Tay4, Audrey Yeo5, Suzanne Yew5, Bernard P. Leung1,6, Wee Shiong Lim5,7

  1. Health and Social Sciences, Singapore Institute of Technology, Singapore
  2. Department of Diagnostic Radiology, Khoo Teck Puat Hospital, Singapore
  3. Department of Diagnostic Radiology, Changi General Hospital, Singapore
  4. Department of General Medicine, Sengkang General Hospital, Singapore
  5. Institute of Geriatrics and Active Ageing, Tan Tock Seng Hospital. Singapore
  6. Department of Rheumatology, Allergy and Immunology, Tan Tock Seng Hospital, Singapore
  7. Department of Geriatric Medicine, Tan Tock Seng Hospital, Singapore
  • *equal contribution

Keywords: Body composition, Dickkopf-1, Monocyte chemotactic protein-1, Sarcopenia, Sarcopenic obesity


Objective: We aim to determine the association of monocyte chemotactic protein-1 (MCP-1) and dickkopft-1 (DKK-1) as potential biomarkers that may predict changes in body composition and physical performance in healthy older adults from Singapore. Methods: Two-hundred community-dwelling older adults (mean age: 67.9 years; 68.5% females) were classified into elevated versus non-elevated groups based on quintile cut-offs of MCP-1 and DKK-1 levels (156.02 pg/mL and 606.31 pg/mL, respectively). Multiple linear regression was performed to examine the relationship between MCP-1 and DKK-1 with body composition and physical performance, adjusted for age, gender and ethnicity. Results: MCP-1 was significantly associated with higher fat mass, fat mass index, percentage body fat, waist circumference and trunk-limb ratio for fat mass (all p<0.01), and repeated chair stand (p=0.004). DKK-1 was not associated with body composition and physical performance measures. Utilising the Asian Working Group for Sarcopenia (AWGS) 2019 criteria, there were 39 (19.5%) sarcopenia and 161 (80.5%) non-sarcopenia participants respectively, with MCP-1 levels significantly higher in sarcopenia compared with non-sarcopenia (p=0.046), but not for DKK-1 (p=0.525). Conclusions: Elevated MCP-1 are associated with changes in fat composition, physical performance and sarcopenia, suggesting its usefulness in identifying at-risk group with sarcopenic obesity.