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JFSF Vol 7, No 3, September 2022, p.117-122

doi: 10.22540/JFSF-07-117


Original Article

A comparison of CT-body composition measurements in non-cancer and cancer patients from a single UK centre

Josh McGovern1, Ross D. Dolan1, Donogh Maguire2, Paul G. Horgan1, Barry J. Laird3, Donald C. McMillan1

  1. Academic Unit of Surgery, School of Medicine, University of Glasgow, New Lister Building, Royal Infirmary, Glasgow, UK
  2. Emergency Department, Glasgow Royal infirmary, UK
  3. Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK

Keywords: Cancer, Obesity, Sarcopenia


Objectives: Establish the prevalence of low skeletal muscle index and density in our population, by comparing age and sex matched cohorts of patients with and without cancer, using standardized methodology for CT-Body composition (CT-BC). Methods: A retrospective analysis of prospectively collected data. Patients admitted to our institution between 17th March 2020 - 1st May 2020, with confirmed coronavirus disease and imaging suitable for CT-BC (n=52), were age and sex matched with patients undergoing resection for colorectal cancer (n=52). Results: 104 patients were included in the final analysis. 43% (n=45) were male, 77% (n=80) were aged 65 years or older, 50% (n=50) were overweight (BMI ≥25) and 53% (n=55) were systemically inflamed (mGPS ≥1). The prevalence of a low SMI (56% vs. 65%) and low SMD (83% vs. 67%) was similar between cohorts. A low SMI and SMD were both associated with age (p<0.05 and p<0.01, respectively) on univariate analysis. On multivariate analysis, a low SMD was independently associated with age (OR 2.38 (1.34-4.22), p=0.003) and mGPS (OR 2.10 (1.20-3.68), p=0.01). Conclusions: In conclusion, the prevalence of a low SMI and low SMD was similar in non-cancer and cancer cohorts in our institution.
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